Health Canada authorizes drug remdesivir for extreme COVID-19 …

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Health Canada has authorized with conditions the drug remdesivir for patients with severe COVID-19, though Canada’s top doctor says the supply is limited.

The drug — which will go by the brand name Veklury — is manufactured by Gilead Sciences Canada.

About Health
Health is a state of physical, mental and social well-being in which disease and infirmity are absent.

Health Canada authorizes drug remdesivir for severe COVID-19 …

About Canada
Canada is a country in the northern part of North America. Its ten provinces and three territories extend from the Atlantic to the Pacific and northward into the Arctic Ocean, covering 9.98 million square kilometres (3.85 million square miles), making it the world’s second-largest country by total area. Its southern and western border with the United States, stretching 8,891 kilometres (5,525 mi), is the world’s longest bi-national land border. Canada’s capital is Ottawa, and its three largest metropolitan areas are Toronto, Montreal, and Vancouver.
Various indigenous peoples inhabited what is now Canada for thousands of years before European colonization. Beginning in the 16th century, British and French expeditions explored and later settled along the Atlantic coast. As a consequence of various armed conflicts, France ceded nearly all of its colonies in North America in 1763. In 1867, with the union of three British North American colonies through Confederation, Canada was formed as a federal dominion of four provinces. This began an accretion of provinces and territories and a process of increasing autonomy from the United Kingdom. This widening autonomy was highlighted by the Statute of Westminster of 1931 and culminated in the Canada Act of 1982, which severed the vestiges of legal dependence on the British parliament.
Canada is a parliamentary democracy and a constitutional monarchy in the Westminster tradition, with a monarch and a prime minister who serves as the chair of the Cabinet and head of government. The country is a realm within the Commonwealth of Nations, a member of the Francophonie and officially bilingual at the federal level. It ranks among the highest in international measurements of government transparency, civil liberties, quality of life, economic freedom, and education. It is one of the world’s most ethnically diverse and multicultural nations, the product of large-scale immigration from many other countries. Canada’s long and complex relationship with the United States has had a significant impact on its economy and culture.
A developed country, Canada has the seventeenth-highest nominal per-capita income globally as well as the thirteenth-highest ranking in the Human Development Index. Its advanced economy is the tenth-largest in the world, relying chiefly upon its abundant natural resources and well-developed international trade networks. Canada is part of several major international and intergovernmental institutions or groupings including the United Nations, NATO, the G7, the Group of Ten, the G20, the United States–Mexico–Canada Agreement and the Asia-Pacific Economic Cooperation forum.

On Tuesday, Health Canada announced the drug is now authorized for use in adults and adolescents aged 12 years and older with a body weight of at least 40 kilograms. 

The company did not seek permission to use the drug to treat pregnant women or children under 12.

Health Canada authorizes drug remdesivir for severe COVID-19 …

In April, a study run by the U.S. National Institutes of Health tested remdesivir versus usual care in 1,063 hospitalized coronavirus patients around the world. It found that the drug reduced the time it takes patients to recover by 31 per cent  — 11 days on average versus 15 days for those just given usual care.

But Dr. Theresa Tam, chief public health officer of Canada, warned that “the supply with this company is very low globally.”

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Remdesivir is administered intravenously and used only in health-care facilities where patients can be closely monitored.

“It’s not something people can go out and access by themselves,” Tam said Tuesday during a press conference.

Because the drug has been given an expedited review, the manufacturer will have to ensure the continued safety, efficacy and quality of the drug, a statement by Health Canada said. 

Remdesivir has also been granted emergency or conditional authorization in the U.S., Europe, Australia, Singapore and Japan.

In Canada, a small number of patients have been or are being treated with the drug under the Special Access Program.

Asked about reports the drug will be expensive, Tam said that may be the case, but the price will be subject to “appropriate reviews.”

“I am aware some of these drugs are going to cost a fair amount of money,” Tam said. “We have to look at access, as well as what’s a reasonable price.”

Matthias Götte, professor and chair of the medical microbiology and immunology department at the University of Alberta, said the drug’s approval is “excellent news.”

“I guess there’s no doubt this is really the the only antiviral agent with with a clear-cut advantage shown in the large clinical trial,” he said. 

Götte explained that the drug targets what he calls “the engine of the virus.”

“This is an enzyme that is absolutely required for replication of the virus, for spread and so forth. So if you target that engine, the virus cannot spread, cannot replicate.” 

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